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KMID : 0857020090240020225
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Kosin Medical Journal
2009 Volume.24 No. 2 p.225 ~ p.227
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Paradoxical Aggravation of a Partial Epilepsy by Oxcarbazepine
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Lee Ji-Hyun
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Abstract
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Oxcarbazepine (OXC), a keto-analogue of carbamazepine (CBZ), is a new anti-epileptic drug considered as a first-line therapy in partial epilepsy. Worsening of seizures by OXC has rarely been reported, but several studies have shown that CBZ has aggravating potential in idiopathic generalized epilepsy. I report a case of a 31 year-old man whose cryptogenic partial epilepsy get worse after OXC treatment. Habitual complex partial seizures were aggravated in a dose-dependent manner during dose increments and were ceased after OXC withdrawal. OXC may aggravate complex partial seizures in cryptogenic partial epilepsy.
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KEYWORD
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Oxcarbazepine, Epilepsy, Adverse effects
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